Nardilysin-Dependent Proteolysis of Cell-Associated VTCN1 (B7-H4) Marks Type 1 Diabetes Development

T-cell responses directed against insulin-secreting pancreatic β-cells are the key events highlighting type 1 diabetes (T1D). Therefore, a defective control of T-cell activation is thought to underlie T1D development. Recent studies implicated a B7-like negative costimulatory protein, V-set domain-c...

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Detalhes bibliográficos
Main Authors: Radichev, Ilian A., Maneva-Radicheva, Lilia V., Amatya, Christina, Parker, Camille, Ellefson, Jacob, Wasserfall, Clive, Atkinson, Mark, Burn, Paul, Savinov, Alexei Y.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2014
Assuntos:
Immunology and Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4171653/
https://ncbi.nlm.nih.gov/pubmed/24848066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db14-0213
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