T cell-recruiting triplebody 19-3-19 mediates serial lysis of malignant B-lymphoid cells by a single T cell

Triplebody 19-3-19, an antibody-derived protein, carries three single chain fragment variable domains in tandem in a single polypeptide chain. 19-3-19 binds CD19-bearing lymphoid cells via its two distal domains and primary T cells via its CD3-targeting central domain in an antigen-specific manner....

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Main Authors: Roskopf, Claudia C., Schiller, Christian B., Braciak, Todd A., Kobold, Sebastian, Schubert, Ingo A., Fey, Georg H., Hopfner, Karl-Peter, Oduncu, Fuat S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Impact Journals LLC 2014
Ábhair:
Research Paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4171644/
https://ncbi.nlm.nih.gov/pubmed/25115385
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