Micronized/ultramicronized palmitoylethanolamide displays superior oral efficacy compared to nonmicronized palmitoylethanolamide in a rat model of inflammatory pain

BACKGROUND: The fatty acid amide palmitoylethanolamide (PEA) has been studied extensively for its anti-inflammatory and neuroprotective actions. The lipidic nature and large particle size of PEA in the native state may limit its solubility and bioavailability when given orally, however. Micronized f...

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Main Authors: Impellizzeri, Daniela, Bruschetta, Giuseppe, Cordaro, Marika, Crupi, Rosalia, Siracusa, Rosalba, Esposito, Emanuela, Cuzzocrea, Salvatore
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2014
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4171547/
https://ncbi.nlm.nih.gov/pubmed/25164769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-014-0136-0
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