Genetic Variants in Transcription Factors Are Associated With the Pharmacokinetics and Pharmacodynamics of Metformin

One-third of type 2 diabetes patients do not respond to metformin. Genetic variants in metformin transporters have been extensively studied as a likely contributor to this high failure rate. Here, we investigate, for the first time, the effect of genetic variants in transcription factors on metformi...

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Hlavní autoři: Goswami, S, Yee, SW, Stocker, S, Mosley, JD, Kubo, M, Castro, R, Mefford, JA, Wen, C, Liang, X, Witte, J, Brett, C, Maeda, S, Simpson, MD, Hedderson, MM, Davis, RL, Roden, DM, Giacomini, KM, Savic, RM
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4171106/
https://ncbi.nlm.nih.gov/pubmed/24853734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2014.109
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