H-Prune through GSK-3β interaction sustains canonical WNT/β-catenin signaling enhancing cancer progression in NSCLC

H-Prune hydrolyzes short-chain polyphosphates (PPase activity) together with an hitherto cAMP-phosphodiesterase (PDE), the latest influencing different human cancers by its overexpression. H-Prune promotes cell migration in cooperation with glycogen synthase kinase-3 (Gsk-3β). Gsk-3β is a negative r...

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Autores principales: Carotenuto, Marianeve, De Antonellis, Pasqualino, Liguori, Lucia, Benvenuto, Giovanna, Magliulo, Daniela, Alonzi, Alessandro, Turino, Cecilia, Attanasio, Carmela, Damiani, Valentina, Bello, Anna Maria, Vitiello, Fabiana, Pasquinelli, Rosa, Terracciano, Luigi, Federico, Antonella, Fusco, Alfredo, Freeman, Jamie, Dale, Trevor C., Decraene, Charles, Chiappetta, Gennaro, Piantedosi, Francovito, Calabrese, Cecilia, Zollo, Massimo
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4170634/
https://ncbi.nlm.nih.gov/pubmed/25026278
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