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Exploiting Innate Immune Cell Activation of a Copper-Dependent Antimicrobial Agent during Infection
Recalcitrant microbial infections demand new therapeutic options. Here we present an approach that exploits two prongs of the host immune cell antimicrobial response: the oxidative burst and the compartmentalization of copper (Cu) within phagolysosomes. The prochelator QBP is a nontoxic protected fo...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4170187/ https://ncbi.nlm.nih.gov/pubmed/25088681 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2014.06.009 |
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