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Utilization of extracellular information before ligand-receptor binding reaches equilibrium expands and shifts the input dynamic range
Cell signaling systems sense and respond to ligands that bind cell surface receptors. These systems often respond to changes in the concentration of extracellular ligand more rapidly than the ligand equilibrates with its receptor. We demonstrate, by modeling and experiment, a general “systems level”...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4169960/ https://ncbi.nlm.nih.gov/pubmed/25172920 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1322761111 |
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