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Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination
Immunoglobulin class-switch recombination (CSR) requires activation-induced cytidine deaminase (AID). Deamination of DNA by AID in transcribed switch (S) regions leads to double-stranded breaks in DNA that serve as obligatory CSR intermediates. Here we demonstrate that the catalytic and regulatory s...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4169875/ https://ncbi.nlm.nih.gov/pubmed/19234474 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1708 |
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