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Functional Role of Autophagy-mediated Proteome Remodeling in Cell Survival Signaling and Innate Immunity

Ras-driven cancer cells upregulate basal autophagy that degrades and recycles intracellular proteins and organelles. Autophagy-mediated proteome degradation provides free amino acids to support metabolism and macromolecular synthesis, which confers a survival advantage in starvation and promotes tum...

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Sonraí Bibleagrafaíochta
Main Authors: Mathew, Robin, Khor, Sinan, Hackett, Sean R., Rabinowitz, Joshua D., Perlman, David H., White, Eileen
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2014
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169768/
https://ncbi.nlm.nih.gov/pubmed/25175026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.07.019
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