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Functional Role of Autophagy-mediated Proteome Remodeling in Cell Survival Signaling and Innate Immunity
Ras-driven cancer cells upregulate basal autophagy that degrades and recycles intracellular proteins and organelles. Autophagy-mediated proteome degradation provides free amino acids to support metabolism and macromolecular synthesis, which confers a survival advantage in starvation and promotes tum...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4169768/ https://ncbi.nlm.nih.gov/pubmed/25175026 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.07.019 |
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