Pharmacological Inhibition of Heat Shock Protein 90 Alleviates Steatosis and Macrophage Activation in Murine Acute and Chronic Alcoholic Liver Injury

BACKGROUND & AIMS: Heat shock protein 90 (hsp90) is an emerging therapeutic target in chronic liver diseases. Hsp90 plays an important role in liver immune cell activation; however its role in alcoholic liver disease (ALD) remains elusive. Here we hypothesize that hsp90 is crucial in alcohol ind...

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Hauptverfasser: Ambade, Aditya, Catalano, Donna, Lim, Arlene, Kopoyan, Andre, Shaffer, Scott A, Mandrekar, Pranoti
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169725/
https://ncbi.nlm.nih.gov/pubmed/24859453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2014.05.024
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