Avian Influenza A H7N9 Virus Induces Severe Pneumonia in Mice without Prior Adaptation and Responds to a Combination of Zanamivir and COX-2 Inhibitor

BACKGROUND: Human infection caused by the avian influenza A H7N9 virus has a case-fatality rate of over 30%. Systematic study of the pathogenesis of avian H7N9 isolate and effective therapeutic strategies are needed. METHODS: BALB/c mice were inoculated intranasally with an H7N9 virus isolated from...

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Detalhes bibliográficos
Main Authors: Li, Can, Li, Chuangen, Zhang, Anna J. X., To, Kelvin K. W., Lee, Andrew C. Y., Zhu, Houshun, Wu, Hazel W. L., Chan, Jasper F. W., Chen, Honglin, Hung, Ivan F. N., Li, Lanjuan, Yuen, Kwok-Yung
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169509/
https://ncbi.nlm.nih.gov/pubmed/25232731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0107966
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