Acid sphingomyelinase is activated in sickle cell erythrocytes and contributes to inflammatory microparticle generation in SCD

Sphingolipids are a class of lipids containing a backbone of sphingoid bases that can be produced de novo through the reaction of palmitate and serine and further metabolized through the activity of various enzymes to produce intermediates with diverse roles in cellular processes and signal transduc...

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Main Authors: Awojoodu, Anthony O., Keegan, Philip M., Lane, Alicia R., Zhang, Yuying, Lynch, Kevin R., Platt, Manu O., Botchwey, Edward A.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2014
Teme:
Red Cells, Iron, and Erythropoiesis
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4168349/
https://ncbi.nlm.nih.gov/pubmed/25075126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-01-543652
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