Acid sphingomyelinase is activated in sickle cell erythrocytes and contributes to inflammatory microparticle generation in SCD

Sphingolipids are a class of lipids containing a backbone of sphingoid bases that can be produced de novo through the reaction of palmitate and serine and further metabolized through the activity of various enzymes to produce intermediates with diverse roles in cellular processes and signal transduc...

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Hlavní autoři: Awojoodu, Anthony O., Keegan, Philip M., Lane, Alicia R., Zhang, Yuying, Lynch, Kevin R., Platt, Manu O., Botchwey, Edward A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2014
Témata:
Red Cells, Iron, and Erythropoiesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4168349/
https://ncbi.nlm.nih.gov/pubmed/25075126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-01-543652
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