DNA-mediated immunization to the hepatitis B surface antigen in mice: aspects of the humoral response mimic hepatitis B viral infection in humans.

Intramuscular injection of plasmid DNA expression vectors encoding the three envelope proteins of the hepatitis B virus (HBV) induced humoral responses in C57BL/6 mice specific to several antigenic determinants of the viral envelope. The first antibodies appeared within 1-2 weeks after injection of...

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Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Michel, M L, Davis, H L, Schleef, M, Mancini, M, Tiollais, P, Whalen, R G
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 1995
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41683/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7777503/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.12.5307
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