siRNAs targeted to Smad4 prevent renal fibrosis in vivo

Renal fibrosis is the final common pathway leading to decreased renal function. No therapy has been established to prevent it. In order to establish a therapeutic approach and target molecule for renal fibrosis, we investigated the effects of Smad4 knockdown by siRNAs on renal fibrosis in vivo. Rena...

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Hlavní autoři: Morishita, Yoshiyuki, Yoshizawa, Hiromichi, Watanabe, Minami, Ishibashi, Kenichi, Muto, Shigeaki, Kusano, Eiji, Nagata, Daisuke
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4168270/
https://ncbi.nlm.nih.gov/pubmed/25236771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep06424
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