5-Lipoxygenase Inhibitors Attenuate TNF-α-Induced Inflammation in Human Synovial Fibroblasts

The lipoxygenase isoform of 5-lipoxygenase (5-LOX) is reported to be overexpressed in human rheumatoid arthritis synovial tissue and involved in the progress of inflammatory arthritis. However, the detailed mechanism of how 5-lipoxygenase regulates the inflammatory response in arthritis synovial tis...

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Détails bibliographiques
Auteurs principaux: Lin, Han-Ching, Lin, Tzu-Hung, Wu, Ming-Yueh, Chiu, Yung-Cheng, Tang, Chih-Hsin, Hour, Mann-Jen, Liou, Houng-Chi, Tu, Huang-Ju, Yang, Rong-Sen, Fu, Wen-Mei
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2014
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4168259/
https://ncbi.nlm.nih.gov/pubmed/25229347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0107890
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