Tax impairs DNA replication forks and increases DNA breaks in specific oncogenic genome regions

BACKGROUND: Human T-cell leukemia virus type 1 (HTLV-I) is a human retrovirus associated with adult T-cell leukemia (ATL), an aggressive CD4 T-cell proliferative disease with dismal prognosis. The long latency preceding the development of the disease and the low incidence suggests that the virus its...

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Detalhes bibliográficos
Main Authors: Chaib-Mezrag, Hassiba, Lemaçon, Delphine, Fontaine, Hélène, Bellon, Marcia, Bai, Xue Tao, Drac, Marjorie, Coquelle, Arnaud, Nicot, Christophe
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4168069/
https://ncbi.nlm.nih.gov/pubmed/25185513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-205
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