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Obesity- and aging-induced excess of central transforming growth factor-β potentiates diabetic development via an RNA stress response
The brain, in particular the hypothalamus, plays a role in regulating glucose homeostasis; however, it remains unclear if the brain is causally involved in diabetic development. Here, we identified that hypothalamic TGF-β is excessive under conditions of not only obesity but aging, which are two gen...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4167789/ https://ncbi.nlm.nih.gov/pubmed/25086906 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3616 |
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