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BRAF V600E immunohistochemistry is reliable in primary and metastatic colorectal carcinoma regardless of treatment status and shows high intratumoral homogeneity

In colorectal carcinoma the evaluation of BRAF mutation status is increasingly being performed given its utility as a prognostic and predictive biomarker. However, there are conflicting reports of the sensitivity and specificity of BRAF V600E immunohistochemistry, and little is known about its relia...

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Detalhes bibliográficos
Main Authors: Bledsoe, Jacob R., Kamionek, Michal, Mino-Kenudson, Mari
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4167743/
https://ncbi.nlm.nih.gov/pubmed/24921639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/PAS.0000000000000263
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