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Adenosine through the A2A adenosine receptor increases IL-1β in the brain contributing to anxiety

Anxiety is one of the most commonly reported psychiatric conditions, but its pathogenesis is poorly understood. Ailments associated with activation of the innate immune system, however, are increasingly linked to anxiety disorders. In adult male mice, we found that adenosine doubled caspase-1 activi...

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Detalhes bibliográficos
Main Authors: Chiu, Gabriel S., Darmody, Patrick T., Walsh, John P., Moon, Morgan L., Kwakwa, Kristin A., Bray, Julie K., McCusker, Robert H., Freund, Gregory G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4167209/
https://ncbi.nlm.nih.gov/pubmed/24907587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2014.05.018
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