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Toward a Rationale for the PTC124 (Ataluren) Promoted Readthrough of Premature Stop Codons: A Computational Approach and GFP-Reporter Cell-Based Assay
[Image: see text] The presence in the mRNA of premature stop codons (PTCs) results in protein truncation responsible for several inherited (genetic) diseases. A well-known example of these diseases is cystic fibrosis (CF), where approximately 10% (worldwide) of patients have nonsense mutations in th...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American
Chemical
Society
2014
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| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4167060/ https://ncbi.nlm.nih.gov/pubmed/24483936 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp400230s |
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