Modular Evolution of DNA-Binding Preference of a Tbrain Transcription Factor Provides a Mechanism for Modifying Gene Regulatory Networks

Gene regulatory networks (GRNs) describe the progression of transcriptional states that take a single-celled zygote to a multicellular organism. It is well documented that GRNs can evolve extensively through mutations to cis-regulatory modules (CRMs). Transcription factor proteins that bind these CR...

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Autores principales: Cheatle Jarvela, Alys M., Brubaker, Lisa, Vedenko, Anastasia, Gupta, Anisha, Armitage, Bruce A., Bulyk, Martha L., Hinman, Veronica F.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2014
Materias:
Discoveries
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4166925/
https://ncbi.nlm.nih.gov/pubmed/25016582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msu213
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