Modular Evolution of DNA-Binding Preference of a Tbrain Transcription Factor Provides a Mechanism for Modifying Gene Regulatory Networks

Gene regulatory networks (GRNs) describe the progression of transcriptional states that take a single-celled zygote to a multicellular organism. It is well documented that GRNs can evolve extensively through mutations to cis-regulatory modules (CRMs). Transcription factor proteins that bind these CR...

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Hlavní autoři: Cheatle Jarvela, Alys M., Brubaker, Lisa, Vedenko, Anastasia, Gupta, Anisha, Armitage, Bruce A., Bulyk, Martha L., Hinman, Veronica F.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
Témata:
Discoveries
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4166925/
https://ncbi.nlm.nih.gov/pubmed/25016582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msu213
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