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Caffeine promotes glutamate and histamine release in the posterior hypothalamus

Histamine neurons are active during waking and largely inactive during sleep, with minimal activity during rapid-eye movement (REM) sleep. Caffeine, the most widely used stimulant, causes a significant increase of sleep onset latency in rats and humans. We hypothesized that caffeine increases glutam...

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Detalhes bibliográficos
Main Authors: John, Joshi, Kodama, Tohru, Siegel, Jerome M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4166758/
https://ncbi.nlm.nih.gov/pubmed/25031227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00114.2014
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