ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development

Endoplasmic reticulum (ER) stress has been implicated in the pathogenesis of viral hepatitis, insulin resistance, hepatosteatosis and non-alcoholic steatohepatitis (NASH), disorders that increase risk of hepatocellular carcinoma (HCC). To determine whether and how ER stress contributes to obesity-dr...

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Bibliographic Details
Main Authors:	Nakagawa, Hayato, Umemura, Atsushi, Taniguchi, Koji, Font-Burgada, Joan, Dhar, Debanjan, Ogata, Hisanobu, Zhong, Zhenyu, Valasek, Mark A., Seki, Ekihiro, Hidalgo, Juan, Koike, Kazuhiko, Kaufman, Randal J., Karin, Michael
Format:	Artigo
Language:	Inglês
Published:	2014
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4165611/ https://ncbi.nlm.nih.gov/pubmed/25132496 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2014.07.001
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ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development

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