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Stem cell senescence. Effects of REAC technology on telomerase-independent and telomerase-dependent pathways

Decline in the gene expression of senescence repressor Bmi1, and telomerase, together with telomere shortening, underlay senescence of stem cells cultured for multiple passages. Here, we investigated whether the impairment of senescence preventing mechanisms can be efficiently counteracted by exposu...

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Bibliografski detalji
Glavni autori: Rinaldi, S., Maioli, M., Pigliaru, G., Castagna, A., Santaniello, S., Basoli, V., Fontani, V., Ventura, C.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4165271/
https://ncbi.nlm.nih.gov/pubmed/25224681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep06373
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