Short Duration of Elevated vIRF-1 Expression during Lytic Replication of Human Herpesvirus 8 Limits Its Ability To Block Antiviral Responses Induced by Alpha Interferon in BCBL-1 Cells

Human herpesvirus 8 (HHV-8) encodes multiple proteins that disrupt the host antiviral response, including viral interferon (IFN) regulatory factor 1 (vIRF-1). The product of the vIRF-1 gene blocks responses to IFN when overexpressed by transfection, but the functional consequence of vIRF-1 that is e...

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Detalhes bibliográficos
Main Authors: Pozharskaya, Veronika P., Weakland, Laura L., Zimring, James C., Krug, Laurie T., Unger, Elizabeth R., Neisch, Andrew, Joshi, Harish, Inoue, Naoki, Offermann, Margaret K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC416518/
https://ncbi.nlm.nih.gov/pubmed/15163753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.12.6621-6635.2004
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