Target Specificity of Human Immunodeficiency Virus Type 1 NCp7 Requires an Intact Conformation of Its CCHC N-Terminal Zinc Finger

The modification of zinc-binding residues inside the conserved CCHC motif of human immunodeficiency virus type 1 NCp7, in particular into CCHH, induces a complete loss of infectivity. Since the mutant His28NCp7 has been shown to be devoid of infectivity in vivo, the structure-function relationships...

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Bibliographic Details
Main Authors:	Ramboarina, S., Druillennec, S., Morellet, N., Bouaziz, S., Roques, B. P.
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology 2004
Subjects:	Replication
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC416507/ https://ncbi.nlm.nih.gov/pubmed/15163759 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.12.6682-6687.2004
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Target Specificity of Human Immunodeficiency Virus Type 1 NCp7 Requires an Intact Conformation of Its CCHC N-Terminal Zinc Finger

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