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Nef Stimulates Human Immunodeficiency Virus Type 1 Replication in Primary T Cells by Enhancing Virion-Associated gp120 Levels: Coreceptor-Dependent Requirement for Nef in Viral Replication

The Nef protein enhances human immunodeficiency virus type 1 (HIV-1) replication through an unknown mechanism. We and others have previously reported that efficient HIV-1 replication in activated primary CD4(+) T cells depends on the ability of Nef to downregulate CD4 from the cell surface. Here we...

詳細記述

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書誌詳細
主要な著者: Lundquist, Christopher A., Zhou, Jing, Aiken, Christopher
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2004
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC416500/
https://ncbi.nlm.nih.gov/pubmed/15163722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.12.6287-6296.2004
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