Genetic Rescue of Glycosylation-deficient Fgf23 in the Galnt3 Knockout Mouse

Fibroblast growth factor 23 (FGF23) is a hormone that inhibits renal phosphate reabsorption and 1,25-dihydroxyvitamin D biosynthesis. The FGF23 subtilisin-like proprotein convertase recognition sequence ((176)RHTR(179)↓) is protected by O-glycosylation through ppGalNAc-T3 (GALNT3) activity. Thus, in...

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Detalhes bibliográficos
Main Authors: Ichikawa, Shoji, Gray, Amie K., Padgett, Leah R., Allen, Matthew R., Clinkenbeard, Erica L., Sarpa, Nicole M., White, Kenneth E., Econs, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2014
Assuntos:
General Endocrinology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4164931/
https://ncbi.nlm.nih.gov/pubmed/25051439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1199
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