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Genetic Rescue of Glycosylation-deficient Fgf23 in the Galnt3 Knockout Mouse
Fibroblast growth factor 23 (FGF23) is a hormone that inhibits renal phosphate reabsorption and 1,25-dihydroxyvitamin D biosynthesis. The FGF23 subtilisin-like proprotein convertase recognition sequence ((176)RHTR(179)↓) is protected by O-glycosylation through ppGalNAc-T3 (GALNT3) activity. Thus, in...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Endocrine Society
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4164931/ https://ncbi.nlm.nih.gov/pubmed/25051439 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1199 |
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