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Chromosome therapy: Correction of large chromosomal aberrations by inducing ring chromosomes in induced pluripotent stem cells (iPSCs)

The fusion of the short (p) and long (q) arms of a chromosome is referred to as a “ring chromosome.” Ring chromosome disorders occur in approximately 1 in 50 000–100 000 patients. Ring chromosomes can result in birth defects, mental disabilities, and growth retardation if additional genes are delete...

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Autori principali: Kim, Taehyun, Bershteyn, Marina, Wynshaw-Boris, Anthony
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4164482/
https://ncbi.nlm.nih.gov/pubmed/25482192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/nucl.36300
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