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Latrunculin B Reduces Intraocular Pressure in Human Ocular Hypertension and Primary Open-Angle Glaucoma

PURPOSE: To evaluate the safety, tolerability, and intraocular pressure (IOP)-lowering effect of Latrunculin-B (Lat-B), a marine macrolide that disrupts the actin cytoskeleton, in patients with ocular hypertension (OHT) or early primary open-angle glaucoma (POAG). METHODS: In this Phase I, multicent...

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Main Authors: Rasmussen, Carol A., Kaufman, Paul L., Ritch, Robert, Haque, Reza, Brazzell, R. Kim, Vittitow, Jason L.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Association for Research in Vision and Ophthalmology 2014
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4164113/
https://ncbi.nlm.nih.gov/pubmed/25237590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/tvst.3.5.1
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