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Whole exome analysis identifies dominant COL4A1 mutations in patients with complex ocular phenotypes involving microphthalmia

Anophthalmia/microphthalmia (A/M) is a developmental ocular malformation defined as complete absence or reduction in size of the eye. A/M is a heterogeneous disorder with numerous causative genes identified; however, about half the cases lack a molecular diagnosis. We undertook whole exome sequencin...

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Detalhes bibliográficos
Main Authors: Deml, Brett, Reis, Linda M., Maheshwari, Mohit, Griffis, Cristin, Bick, David, Semina, Elena V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4163542/
https://ncbi.nlm.nih.gov/pubmed/24628545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cge.12379
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