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FGF maintains chondrogenic potential of limb bud mesenchymal cells by modulating DNMT3A recruitment
The formation of cartilage is restricted to the core of the limb bud mesenchyme by ectodermal Wnts, which can irreversibly silence expression of the prochondrogenic transcription factor Sox9. In contrast, fibroblast growth factor (FGF) signals from the apical ectodermal ridge maintain the competence...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4163101/ https://ncbi.nlm.nih.gov/pubmed/25159139 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.07.038 |
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