Gene disruption of a G4-DNA-dependent nuclease in yeast leads to cellular senescence and telomere shortening.
The yeast gene KEM1 (also named SEP1/DST2/XRN1/RAR5) produces a G4-DNA-dependent nuclease that binds to G4 tetraplex DNA structure and cuts in a single-stranded region 5' to the G4 structure. G4-DNA generated from yeast telomeric oligonucleotides competitively inhibits the cleavage reaction, suggest...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1995
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41630/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7597069/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.13.6002 |
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