A Novel, Live-Attenuated Vesicular Stomatitis Virus Vector Displaying Conformationally Intact, Functional HIV-1 Envelope Trimers That Elicits Potent Cellular and Humoral Responses in Mice

Though vaccination with live-attenuated SIV provides the greatest protection from progressive disease caused by SIV challenge in rhesus macaques, attenuated HIV presents safety concerns as a vaccine; therefore, live viral vectors carrying HIV immunogens must be considered. We have designed a replica...

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Detalhes bibliográficos
Main Authors: Rabinovich, Svetlana, Powell, Rebecca L. R., Lindsay, Ross W. B., Yuan, Maoli, Carpov, Alexei, Wilson, Aaron, Lopez, Mary, Coleman, John W., Wagner, Denise, Sharma, Palka, Kemelman, Marina, Wright, Kevin J., Seabrook, John P., Arendt, Heather, Martinez, Jennifer, DeStefano, Joanne, Chiuchiolo, Maria J., Parks, Christopher L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4162551/
https://ncbi.nlm.nih.gov/pubmed/25215861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0106597
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