Receptor Tyrosine Kinases, TYRO3, AXL, and MER, Demonstrate Distinct Patterns and Complex Regulation of Ligand-induced Activation

TYRO3, AXL, and MER receptors (TAMs) are three homologous type I receptor-tyrosine kinases that are activated by endogenous ligands, protein S (PROS1) and growth arrest-specific gene 6 (GAS6). These ligands can either activate TAMs as soluble factors, or, in turn, opsonize phosphatidylserine (PS) on...

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Hlavní autoři: Tsou, Wen-I, Nguyen, Khanh-Quynh N., Calarese, Daniel A., Garforth, Scott J., Antes, Anita L., Smirnov, Sergey V., Almo, Steve C., Birge, Raymond B., Kotenko, Sergei V.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4162177/
https://ncbi.nlm.nih.gov/pubmed/25074926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.569020
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