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CDK4/6 inhibition provides a potent adjunct to Her2-targeted therapies in preclinical breast cancer models

In spite of the efficacy of Her2-targeted therapies, recurrence and progression remain a challenge for treatment of Her2 positive breast cancer. CDK4/6 controls pathway downstream of Her2, Inhibition of these kinases could represent an important therapeutic approach to augment the effectiveness of s...

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Detalhes bibliográficos
Main Authors: Witkiewicz, Agnieszka K., Cox, Derek, Knudsen, Erik S.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4162138/
https://ncbi.nlm.nih.gov/pubmed/25221644
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