Prognostic prediction of glioblastoma by quantitative assessment of the methylation status of the entire MGMT promoter region

BACKGROUND: O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation is reported to be a prognostic and predictive factor of alkylating chemotherapy for glioblastoma patients. Methylation specific PCR (MSP) has been most commonly used when the methylation status of MGMT is assessed. Howeve...

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Bibliographic Details
Main Authors: Kanemoto, Manabu, Shirahata, Mitsuaki, Nakauma, Akiyo, Nakanishi, Katsumi, Taniguchi, Kazuya, Kukita, Yoji, Arakawa, Yoshiki, Miyamoto, Susumu, Kato, Kikuya
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4161852/
https://ncbi.nlm.nih.gov/pubmed/25175833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-641
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