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Hydroxymethylated Cytosines Are Associated with Elevated C to G Transversion Rates

It has long been known that methylated cytosines deaminate at higher rates than unmodified cytosines and constitute mutational hotspots in mammalian genomes. The repertoire of naturally occurring cytosine modifications, however, extends beyond 5-methylcytosine to include its oxidation derivatives, n...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Supek, Fran, Lehner, Ben, Hajkova, Petra, Warnecke, Tobias
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4161303/
https://ncbi.nlm.nih.gov/pubmed/25211471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004585
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