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A Mycobacterium tuberculosis Cytochrome bd Oxidase Mutant Is Hypersensitive to Bedaquiline
The new medicinal compound bedaquiline (BDQ) kills Mycobacterium tuberculosis by inhibiting F(1)F(o)-ATP synthase. BDQ is bacteriostatic for 4 to 7 days and kills relatively slowly compared to other frontline tuberculosis (TB) drugs. Here we show that killing with BDQ can be improved significantly b...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society of Microbiology
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4161257/ https://ncbi.nlm.nih.gov/pubmed/25028424 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01275-14 |
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