New Praziquantel Derivatives Containing NO-donor Furoxans and Related Furazans as Active Agents against Schistosoma mansoni

A series of NO-donor praziquantel hybrid compounds was obtained by combining praziquantel (PZQ) and furoxan moieties in a single entity. NO-donor properties of the furoxan derivatives were evaluated by detecting nitrite after incubation of the products in 7.4 pH buffered solution in the presence of...

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Главные авторы: Guglielmo, Stefano, Cortese, Daniela, Vottero, Francesca, Rolando, Barbara, Kommer, Valerie P., Williams, David L., Fruttero, Roberta, Gasco, Alberto
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4160910/
https://ncbi.nlm.nih.gov/pubmed/25016371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2014.07.007
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