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Resistance to Tyrosine Kinase Inhibition Therapy for Chronic Myelogenous Leukemia: A Clinical Perspective and Emerging Treatment Options

The development of tyrosine kinase inhibitors (TKIs) has led to extended lifespans for many patients with chronic myelogenous leukemia (CML). However, 20% to 30% of patients fail to respond, respond suboptimally, or experience disease relapse after treatment with imatinib. A key factor is drug resis...

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Detalhes bibliográficos
Main Authors: Jabbour, Elias J., Cortes, Jorge E., Kantarjian, Hagop M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4160831/
https://ncbi.nlm.nih.gov/pubmed/23890944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clml.2013.03.018
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