Anti-apoptotic BCL-2 proteins govern cellular outcome following B-RAF(V600E) inhibition and can be targeted to reduce resistance

In theory, pharmacological inhibition of oncogenic signaling is an effective strategy to halt cellular proliferation, induce apoptosis, and eliminate cancer cells. In practice, drugs (e.g., PLX-4032) that inhibit oncogenes like B-RAF(V600E) provide relatively short-term success in patients, due to a...

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Main Authors: Serasinghe, Madhavika N., Missert, Derek J., Asciolla, James J., Wieder, Shira Y., Podgrabinska, Simona, Izadmehr, Sudeh, Belbin, Gillian, Skobe, Mihaela, Chipuk, Jerry E.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4160434/
https://ncbi.nlm.nih.gov/pubmed/24608435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.21
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