The Poly(Adenosine Diphosphate-Ribose) Polymerase Inhibitor PJ34 Reduces Pulmonary Ischemia-Reperfusion Injury in Rats

BACKGROUND: Ischemia-reperfusion (I/R) injury after lung transplantation causes alveolar damage, lung edema, and acute rejection. Poly(adenosine diphosphate-ribose) polymerase (PARP) is a single-stranded DNA repair enzyme that induces apoptosis and necrosis after DNA damage caused by reactive oxygen...

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Autori principali: Hatachi, Go, Tsuchiya, Tomoshi, Miyazaki, Takuro, Matsumoto, Keitaro, Yamasaki, Naoya, Okita, Naoyuki, Nanashima, Atsushi, Higami, Yoshikazu, Nagayasu, Takeshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Lippincott Williams & Wilkins 2014
Soggetti:
Basic and Experimental Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4160283/
https://ncbi.nlm.nih.gov/pubmed/25221900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0000000000000305
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