Overexpression and Constitutive Nuclear Localization of Cohesin Protease Separase Protein Correlates with High Incidence of Relapse and Reduced Overall Survival in Glioblastoma Multiforme

Separase, an enzyme that cleaves the chromosomal cohesin during mitosis, is overexpressed in a wide range of human epithelial cancers of breast, bone and prostate [Meyer et al, 2009, Clin Cancer Res 15(8): 2703-2710] [1]. Overexpression of Separase in animal models results in aneuploidy and tumorige...

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Главные авторы: Mukherjee, Malini, Byrd, Tiara, Brawley, Vita S., Bielamowicz, Kevin, Li, Xiao-Nan, Merchant, Fatima, Maitra, Saurabh, Sumazin, Pavel, Fuller, Greg, Kew, Yvonne, Sun, David, Powell, Suzanne Z., Ahmed, Nabil M., Zhang, Nenggang, Pati, Debananda
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4160150/
https://ncbi.nlm.nih.gov/pubmed/24792645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-014-1458-6
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