A Functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p21 expression in human cancer

In a genome-wide survey on somatic copy number alterations (SCNAs) of long non-coding RNA (lncRNA) in 2,394 tumor specimens from 12 cancer types, we found that about 21.8% of lncRNA genes were located in regions with focal SCNAs. By integrating bioinformatics analyses of lncRNA SCNAs and expression...

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Autori principali: Hu, Xiaowen, Feng, Yi, Zhang, Dongmei, Zhao, Sihai D, Hu, Zhongyi, Greshock, Joel, Zhang, Youyou, Yang, Lu, Zhong, Xiaomin, Wang, Li-Ping, Jean, Stephanie, Li, Chunsheng, Huang, Qihong, Katsaros, Dionyssios, Montone, Kathleen T., Tanyi, Janos L., Lu, Yiling, Boyd, Jeff, Nathanson, Katherine L., Li, Hongzhe, Mills, Gordon B., Zhang, Lin
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4159613/
https://ncbi.nlm.nih.gov/pubmed/25203321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2014.07.009
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