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Tonic inhibition in dentate gyrus impairs long-term potentiation and memory in an Alzhiemer’s disease model

Amyloid plaques and tau tangles are common pathological hallmarks for Alzheimer’s disease (AD), however reducing Aβ production failed to relieve the symptoms of AD patients. Here we report a high GABA (γ-aminobutyric acid) content in reactive astrocytes in the dentate gyrus (DG) of a mouse model for...

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Bibliografiska uppgifter
Huvudupphovsmän: Wu, Zheng, Guo, Ziyuan, Gearing, Marla, Chen, Gong
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4159602/
https://ncbi.nlm.nih.gov/pubmed/24923909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5159
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