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Hydrodynamic Delivery of FGF21 Gene Alleviates Obesity and Fatty Liver in Mice Fed a High-fat Diet

FGF21 is a secreted protein that plays critical roles in regulating glucose and lipid metabolism. In this study, we evaluated the effects of FGF21 gene transfer on C57BL/6 mice fed a high fat diet (HFD). We demonstrate that transfer of the FGF21 gene using a hydrodynamics-based procedure increased m...

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Bibliografiske detaljer
Main Authors: Gao, Mingming, Ma, Yongjie, Cui, Ran, Liu, Dexi
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4159144/
https://ncbi.nlm.nih.gov/pubmed/24747761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2014.03.047
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