Association between BRCA2 but not BRCA1 Mutations and Beneficial Survival, Chemotherapy Sensitivity, and Gene Mutator Phenotype in Patients with Ovarian Cancer

CONTEXT: Attempts to determine the clinical significance of BRCA1/2 mutations in ovarian cancer (OvCa) have produced conflicting results. OBJECTIVE: To determine the relationships between BRCA1/2 deficiency (i.e., mutation and promoter hypermethylation) and overall survival (OS), progression-free su...

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Hlavní autoři: Yang, Da, Khan, Sofia, Sun, Yan, Hess, Kenneth, Shmulevich, Ilya, Sood, Anil K., Zhang, Wei
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4159096/
https://ncbi.nlm.nih.gov/pubmed/21990299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.2011.1456
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