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Arylamine N-acetyltransferases: from drug metabolism and pharmacogenetics to drug discovery
Arylamine N-acetyltransferases (NATs) are polymorphic drug-metabolizing enzymes, acetylating arylamine carcinogens and drugs including hydralazine and sulphonamides. The slow NAT phenotype increases susceptibility to hydralazine and isoniazid toxicity and to occupational bladder cancer. The two poly...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BlackWell Publishing Ltd
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4158862/ https://ncbi.nlm.nih.gov/pubmed/24467436 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12598 |
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